Hydroxychloroquine

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Structural diagram of hydroxychloroquine.

Hydroxychloroquine (HCQ), sold under the brand name Plaquenil among others, is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine.

Quotes[edit]

  • We are issuing this joint statement to highlight the important role that physicians, pharmacists and health systems play in being just stewards of health care resources during times of emergency and national disaster. We are aware that some physicians and others are prophylactically prescribing medications currently identified as potential treatments for COVID-19 (e.g., chloroquine or hydroxychloroquine, azithromycin) for themselves, their families, or their colleagues; and that some pharmacies and hospitals have been purchasing excessive amounts of these medications in anticipation of potentially using them for COVID-19 prevention and treatment. We strongly oppose these actions. At the same time, we caution hospitals, health systems, and individual practitioners that no medication has been FDA-approved for use in COVID-19 patients, and there is no incontrovertible evidence to support off-label use of medications for COVID-19. Stockpiling these medications—or depleting supplies with excessive, anticipatory orders—can have grave consequences for patients with conditions such as lupus or rheumatoid arthritis if the drugs are not available in the community. The health care community must collectively balance the needs of patients taking medications on a regular basis for an existing condition with new prescriptions that may be needed for patients diagnosed with COVID-19. Being just stewards of limited resources is essential.
  • We are further concerned by the confusion that may result from various state government agencies and boards issuing emergency rules limiting or restricting access to chloroquine, hydroxychloroquine or other emerging therapies or requiring new procedures for physicians and other healthcare professionals and patients. If these bodies promulgate new rules, we urge that they emphasize professional responsibility and leave room for professional judgment. We further urge that patients already on these medications should not be impacted by new laws, rules or other guidance. In a time of national pandemic, now is not the time for states to issue conflicting guidance, however well-intentioned, that could lead to unintended consequences. We applaud the ongoing efforts to conduct clinical trials and generate evidence related to these and other medications during a time of pandemic. We are also encouraged that some pharmaceutical manufacturers are increasing production of high-demand medications as well as supplying them for use in clinical trials.
  • Standing alongside two top public health officials who have declined to endorse his call for widely administering the drug, Mr. Trump suggested that he was speaking on gut instinct and acknowledged that he had no expertise on the subject. Saying that the drug is "being tested now," Mr. Trump said that "there are some very strong, powerful signs" of its potential, although health experts say that the data is extremely limited and that more study of the drug's effectiveness against the coronavirus is needed. [...] Mr. Trump, who once predicted that the virus might "miraculously" disappear by April because of warm weather, and who has rejected scientific consensus on issues like climate change, was undaunted by skeptical questioning. "What do you have to lose?" Mr. Trump asked, for the second day in a row, saying that terminally ill patients should be willing to try any treatment that has shown some promise.
  • Hydroxychloroquine has not been proved to work against Covid-19 in any significant clinical trials. A small trial by Chinese researchers made public last week found that it helped speed the recovery in moderately ill patients, but the study was not peer-reviewed and had significant limitations. Earlier reports from France and China have drawn criticism because they did not include control groups to compare treated patients with untreated ones, and researchers have called the reports anecdotal. Without controls, they said, it is impossible to determine whether the drugs worked. But Mr. Trump on Sunday dismissed the notion that doctors should wait for further study.
  • Now we're working with the states in almost all instances, but we have a great system. And the other thing that we bought a tremendous amount of is the hydroxy chloroquine]]. Hydroxy chloroquine, which I think is, you know, it's a great malaria drug. It's worked unbelievably. It's a powerful drug on malaria and there are signs that it works on this, some very strong signs and in the meantime it's been around a long time. It also works very powerfully on lupus, so there are some very strong powerful signs and we'll have to see because again, it's tested.
  • Now this is a new thing that just happened to as the invisible enemy we call it. And if you can, if you have a no signs of heart problems, the azithromycin, which will kill certain things that you don't want living within your body. It's a powerful drug. If you don't have a problem, a heart problem, we would say, let your doctor think about it, but as a combination, I think they're going to be, I think there's two things that should be looked at very strongly. Now, we have purchased and we have stockpiled 29 million pills of the hydroxy chloroquine, 29 million. A lot of drug stores have them by prescription and also, and they're not expensive. Also, we're sending them to various labs. Our military, we're sending them to the hospitals, we're sending them all over. I just think it's something, you know the expression, I've used it for certain reasons.
  • What do you have to lose? What do you have to lose? And a lot of people are saying that when … and are taking it, if you're a doctor, a nurse, a first responder, a medical person going into hospitals, they say taking it before the fact is good, but what do you have to lose? They say, take it, I'm not looking at it one way or the other, but we want to get out of this. If it does work, it would be a shame if we didn't do it early. But we have some very good signs. So that's hydroxy chloroquine and as azithromycin, and again, you have to go through your medical people get the approval. But I've seen things that I sort of like, so what do I know? I'm not a doctor, I'm not a doctor, but I have common sense.
  • The FDA feels good about it. They've, as you know, they've approved it. They gave it a rapid approved approval. And the reason because it's been out there for a long time and they know the side effects and they also know the potential. So based on that, we have sent it throughout the country. We have it stockpiled about 29 million doses, 29 million doses. We have a lot of it. We hope it works. Driven by the goal of the brightest minds in science. We have the brightest minds in science, but we were driven by the goal of getting rid of this plague, getting rid of this scourge, getting rid of this virus. These brilliant minds are working on the most effective antiviral therapies and vaccines. We are working very, very hard. I have met many of the doctors that are doing it. These are doctors that are working so hard on vanquishing the virus.
  • I want them to try it. It may work, and it may not work. But if it doesn't work, it's nothing lost by doing it. Nothing. Because we know long-term what I want. I want to save lives, and I don't want it to be in a lab for the next year-and-a-half as people are dying all over the place. In France, they had a very good test. They're continuing. But we don't have time to go and say, gee, let's take a couple of years and test it out, and let's go and test with the test tubes and the laboratories. We don't have time. I'd love to do that, but we have people dying today. As we speak, there are people dying. If it works, that'd be great. If it doesn't work, we know for many years malaria, it's incredible what it's done for malaria. It's incredible what it's done for lupus, but it doesn't kill people.
  • Speaker to Anthony Fauci: And would you also weigh in on this issue of hydroxychloroquine? What do you think about this and what is the medical evidence?
Donald Trump: You know how many times he's answered that question?
Speaker: I'd love to hear from the doctor.
Donald Trump: Maybe 15. 15 times. You don't have to ask the question.
Speaker: He's your medical expert, correct?
Donald Trump: He answered that question 15 times.
  • Fauci suppressed off-label use of hydroxychloroquine by encouraging discussions of it to be pulled from social media, by sabotaging its clinical trials by testing doses six times the recommended levels (p. 26), and by pulling sixty-three million doses of the medicine off the market, safely away from covid sufferers they could have helped (p. 28). Fauci also provided cover for those who threatened doctors and pharmacists with loss of licenses and jobs for prescribing and dispensing hydroxychloroquine for covid (pp. 31–32). The story of ivermectin is similar.

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