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Acetylcholine is an organic chemical that functions in the brain and body of many types of animals, including humans, as a neurotransmitter—a chemical released by nerve cells to send signals to other cells. Its name is derived from its chemical structure: it is an ester of acetic acid and choline.


  • The question of a possible physiological significance, in the resemblance between the action of choline esters and the effects of certain divisions of the involuntary nervous system, is one of great interest, but one for the discussion of which little evidence is available. Acetyl-choline is, of all the substances examined, the one whose action is most suggestive in this direction. The fact that its action surpasses even that of adrenaline, both in intensity and evanescence, when considered in conjunction with the fact that each of these two bases reproduces those effects of involuntary nerves which are absent from the action of the other, so that the two actions are in many directions at once complementary and antagonistic, gives plenty of scope for speculation.
    • Sir Henry Hallett Dale, "The Action of Certain Esters and Ethers of Choline, and Their Relation to Muscarine", The Journal of Pharmacology and Experimental Therapeutics, Volume 6, 1914–15 (p. 188)

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