Babe is a slang term of endearment. It may refer to:
- Babe Ruth (1895–1948), American Major League baseball player
- The Babe, a 1992 film about Babe Ruth
- Babe (film), a 1995 Australian film about an anthropomorphic pig
- "Babe", a 1979 song by Styx from their album Cornerstone
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