Cascade reaction

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A cascade reaction or tandem reaction or domino reaction is a consecutive series of intramolecular organic reactions which often proceed via highly reactive intermediates.


  • Domino-type reactions involve careful design of a multistep reaction in a one-pot sequence in which the first step creates the functionality to trigger the second reaction and so on, making this approach economical and environmentally friendly.
    • George S. Zweifel and Michael H. Nantz Modern Organic Synthesis (2006), Ch. 1. Synthetic Design.

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