Francis Harry Compton Crick (8 June 1916 – 28 July 2004) was a British physicist, molecular biologist and neuroscientist, most noted for being one of the co-discoverers of the structure of the DNA molecule in 1953.
- See also: The Astonishing Hypothesis
Of Molecules and Men (1966)
- The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
- Seattle: University of Washington Press, 1966, p. 10.
- And so to those of you who may be vitalists I would make this prophecy: what everyone believed yesterday, and you believe today, only cranks will believe tomorrow.
Life Itself: Its Origin and Nature (1981)
- An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going. But this should not be taken to imply that there are good reasons to believe that it could not have started on the earth by a perfectly reasonable sequence of fairly ordinary chemical reactions. The plain fact is that the time available was too long, the many microenvironments on the earth's surface too diverse, the various chemical possibilities too numerous and our own knowledge and imagination too feeble to allow us to be able to unravel exactly how it might or might not have happened such a long time ago, especially as we have no experimental evidence from that era to check our ideas against.
- New York NY: Simon & Schuster, 1981, p. 88.
- If for example I had some idea, which as it turned out would be quite wrong, was going off of the tangent, Watson would tell me in no uncertain terms this was nonsense, and vice-versa. If he would have some idea I didn't like, and I would say so, this would shake his thinking about, and draw him back again. And in fact it is one of the requirements for collaborations of this sort, is you must be perfectly candid, one might almost say rude, to the person you're working with. It's useless working with somebody who is either much too junior than yourself or much too senior because then politeness creeps in. And this is the end of all real collaboration in science (giggles).
The DNA Story (1973, film, VSM Productions)
- I wasn't aware of Chargaff's rules when he said them, but the effect on me was quite electric because I realized immediately that if you had this sort of scheme that John Griffith was proposing, of adenine being paired with thymine, and guanine being paired with cytosine, then you should get Chargaff's rules.I was very excited, but I didn't actually tell Chargaff because it was something I was doing with John Griffith. ... This was very exciting, and we thought "ah ha!" and we realized - I mean what anyone who is familiar with the history of science ought to realize - that when you have one-to-one ratios, it means things go to together. And how on Earth no one pointed out this simple fact in those years, I don't know.
Life Story (1987, BBC)
- Big questions get big answers.
What Mad Pursuit (1988)
- I argued that it was important not to place too much reliance on any single piece of experimental evidence. It might turn out to be misleading, as the 5.1 Å reflection undoubtedly was. Jim was a little more brash, stating that no good model ever accounted for all the facts, since some data was bound to be misleading if not plain wrong. A theory that did fit all the data would have been "carpentered" to do so and would thus be open to suspicion. (pp. 59-60)
- Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
- Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene.
- What is found in biology is mechanisms, mechanisms built with chemical components and that are often modified by other, later, mechanisms added to the earlier ones. While Occam's razor is a useful tool in the physical sciences, it can be a very dangerous implement in biology. It is thus very rash to use simplicity and elegance as a guide in biological research. While DNA could be claimed to be both simple and elegant, it must be remembered that DNA almost certainly originated fairly close to the origin of life when things were necessarily simple or they would not have got going.
Biologists must constantly keep in mind that what they see was not designed, but rather evolved. It might be thought, therefore, that evolutionary arguments would play a large part in guiding biological research, but this is far from the case. It is difficult enough to study what is happening now. To figure out exactly what happened in evolution is even more difficult. Thus evolutionary achievements can be used as hints to suggest possible lines of research, but it is highly dangerous to trust them too much. It is all too easy to make mistaken inferences unless the process involved is already very well understood.
- The job of theorists, especially in biology, is to suggest new experiments. A good theory makes not only predictions, but surprising predictions that then turn out to be true. (If its predictions appear obvious to experimentalists, why would they need a theory?)
- My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure,” I was supposed to have said in my molecular biology days. (I believe I was sailing at the time.) I think that one should approach these problems at all levels, as was done in molecular biology. Classical genetics is, after all, a black-box subject. The important thing was to combine it with biochemistry. In nature hybrid species are usually sterile, but in science the reverse is often true. Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.