Needs closer look
This article needs a closer look to see if the quotes in the unsourced section are properly referenced and also to make sure that the entry follows the new standards to make sure entries are not copyright violations. FloNight♥♥♥ 13:03, 20 October 2008 (UTC)
Wikiquote no longer allows unsourced quotations, and they are in process of being removed from our pages (see Wikiquote:Limits on quotations); but if you can provide a reliable and precise source for any quote on this list please move it to Hugh Laurie.
- I probably use humor to try and avoid getting close to people, in a funny sort of way. Making people laugh is sort of cowardly. It can be an intimate thing, but it also distances you from the person somewhat.
- Guilt I can do. If [I have] any expertise at all, it's in the area of guilt. I have a black belt in guilt. If you ever want a guilt-off, the next time we meet let's see how we match up. I'm pretty confident in that area.
- I admit I can't shake the idea that there is virtue in suffering, that there is a sort of psychic economy, whereby if you embrace success, happiness and comfort, these things have to be paid for.
- The buildings and the cruelty. They're very harsh people, the British: hard to impress, very tough on each other, but I rather like that. It's not that the British are more honest - you're just under no illusion with them. L.A. runs on optimism, enthusiasm and flattery. I think you can go a little bit crazy. I've heard people say there's a limit to the number of years you can stay in this city without going slightly mad. It's just too damn sunny in every dimension - weather-wise, socially and professionally.
- I picked a reverence for medicine because I rather hero-worshiped my father [a former doctor], and because I admire doctors, I admire study, empiricism and rational thought. I don't admire crystals and chewing willow bark and herbal remedies.
- I've lost all lingering hopes of maturity. I took a wrong turn somewhere around 10. Mind you, it might be nice if my voice broke. 
- Boredom is not an appropriate response to exploding cars- on when he figured out he had depression.
- I was not consciously imitating [MacDonald Fraser's series] Flashman. I have never heard anyone say before that my work resembles Fraser's and I don't see how it does. But that really is a superb compliment. It's a real feather in my cap, even if the guy who wrote that Times review is deranged. (Commenting on the New York Times review of his novel, The Gun Seller) 
- People here drive like baboons on crack - they've stolen the keys and sort of figured out how to switch the thing on. I'm just staggered by it.(On driving in L.A.)
- There's the clown in House, there's an adolescent in him, a child, a playful side. There's also a tormented self-destroyer as well. I get the best of all possible worlds.
- Tarantino is fantastically entertaining. Kill Bill is about as much fun as you can have in a theater. And I have to see any Clint Eastwood film. I've seen all his movies, some an embarrassing number of times.
- That's plainly absurd....What I am - and I'm sure everyone knows this - is a profoundly unsexy person playing a sexy character. (On being told he is the "thinking woman's sex symbol", after his success on House, M.D.)