Peter Hotez (born 5 May 1958) is an American scientist, pediatrician, and advocate in the fields of global health, vaccinology, and neglected tropical disease control. He serves as founding dean of the National School of Tropical Medicine and Professor of Pediatrics and Molecular Virology & Microbiology at Baylor College of Medicine, where he is also Director of the Texas Children's Hospital Center for Vaccine Development and Texas Children’s Hospital Endowed Chair in Tropical Pediatrics. Hotez served previously as President of the American Society of Tropical Medicine and Hygiene and is a founding Editor-in-Chief of PLOS Neglected Tropical Diseases. He is also the co-director of Parasites Without Borders, a global nonprofit organization with a focus on those suffering from parasitic diseases in subtropical environments.
- There's still no road map for what you do to make a vaccine in the midst of a devastating public health outbreak.
- Peter Hotez (2020) cited in "Experts scramble, but new virus vaccine may not come in time" on Jamaica Observer, 8 February 2020.
Blue Marble Health (2016)
: An Innovative Plan to Fight Diseases of the Poor Amid Wealth
- In 2006, I became founding editor in chief of PLOS Neglected Tropical Diseases, a then new journal for a growing community of scientists and public health officials committed to studying the neglected tropical diseases (NTDs). ...I became deeply impressed with the number of papers reporting on disease findings in middle-income countries, and even in some high-income countries. This... combined with my personal experiences after moving to Texas and seeing first-hand the endemic tropical diseases, inspired me to look more deeply into the health disparities of the poor who live in the midst of wealth. ...Many of the findings in this book are based on data and information published in [the journal].
- In 2011, together with a team of 15 scientists, I relocated to Houston, Texas, to launch a new school devoted to poverty-related diseases. The National School of Tropical Medicine at Baylor College of Medicine is a joint venture among three biomedical institutions—Baylor, Texas Children's Hospital, and the Sabin Vaccine Institute—with a mission devoted to research on and training in the treatment of neglected tropical diseases, or NTDs...
- Today, the NTDs represent the most common afflictions of people who live in extreme poverty. These ailments include diseases such as hookworm, schistosomiasis, Chagas disease, and sleishmaniasis—or... the most important diseases you've never heard of. Virtually every impoverished individual is infected with at least one NTD.
- Baylor's National School of Tropical Medicine... includes as its research arm a... product development partnership (PDP). There are 16 PDPs worldwide... international nonprofit organizations that develop and manufacture biopharmaceuticals—drugs, diagnostics, and vaccines—for NTDs, as well as for HIV/AIDS, tuberculosis (TB), and malaria. Together, the NTDs, Tb, and malaria are sometimes broadly defined as "neglected diseases." PDPs develop and test new products for neglected diseases that the major pharmaceutical companies may not have an interest in because they are poverty-related afflictions that will therefor not generate significant sales income. The National School of Tropical Medicine's PDP is known as the Sabin Vaccine Institute PDP, and it is specifically focused on developing NTD vaccines.
- One reason... to move our scientists to Houston was to take advantage of being located within the Texas Medical Center [TMC]... comprising more than 50 biomedical institutions and 100,000 employees, occupying a building space that exceeds that of downtown Los Angeles. A second reason... generous support from Texas Children's Hospital (the world's largest...) which also housed the Sabin Vaccine Institute PDP... Our goal for moving and becoming linked to the TMC was to increase the number of new vaccines we are creating for the poorest people in less developed countries, [and] to accelerate the pace at which they are produced. ...[T]oday we have two vaccines in clinical trials—with others in various stages of development.
- [I]n Houston (and elsewhere in Texas) is an area known as the Fifth Ward... Driving... deep into this neighborhood reminded me of the terrible poverty I had seen... in destitute areas of Honduras, Guatemala, Brazil, and China. I saw... images... just like the standard global disease movie typically shown to first-year public health or medical students. ...It was even more astonishing when we turned our global health lens inward to study diseases that were infecting impoverished areas... [W]e found widespread NTDs... in Texas and elsewhere in the southern United States. ...NTDs are first and foremost diseases of acute poverty. ...[W]e determined that 12 million Americans who live at such poverty levels suffer from at least one NTD. The diseases include neglected parasitic infections such as Chagas disease, cysticercosis, toxocariasis, and trichomoniasis.
Vaccines Did Not Cause Rachel's Autism (2018)
Note: Rachel is the daughter of Peter and Ann Hotez.
- Today, measles ranks among the most deadly of childhood infections, yet parents and guardians are walking away from protecting their children against this and other deadly diseases in unprecedented numbers. They are abandoning the option of protecting their children because of phony propaganda released by an anti-vaccine movement that began in 1968. Since then, the movement has become scary, powerful, and well organized. One aspiration of this book is to counter [those] claims... that MMR (measles, mumps-rubella) and other childhood vaccines are either unsafe or cause autism.
- [V]accines are safe and cannot possibly cause autism...
- I perceive... a dearth of voices speaking out against the modern anti-vaccination movement. Their false claims and public statements more often than not go unchallenged. I hope that this book might serve as a clarion call for other scientists and physicians to speak out on behalf of science.
- There is an urgency to create vaccines for diseases which don't make money.
- [W]e took this on... with the idea of pioneering not only interest in science, but also a new business model, and the business model part, we haven't quite figured out yet, because we're trying to make... vaccines for diseases no one else will make.
- So we have a Schistosomiasis vaccine now in clinical trials, a Leishmaniasis vaccine that we hope will advance to the clinic soon, a Hookworm vaccine in clinical trials, a new Chagas disease vaccine that's moving into the clinic. I like to say that these are the most important diseases that you've never heard of. These are some of the most common afflictions of the world's population, but they mostly occur among people who live in extreme poverty... [S]o there is no model to figure out who's going to pay for them. So as a consequence, neither the biotechs nor the big pharmaceutical companies make those vaccines.
- [W]e also took on, a decade ago, the interesting problem of making Coronavirus vaccines because we recognized these as enormous public health threats, and yet we have not seen the big pharma guys and the biotech's rushing into this space. So we... partnered with a group at the New York Blood Center and the Galveston National Laboratory to take on the big scientific challenge of Coronavirus vaccines...
- [O]ne of the things that we're not hearing a lot about is the unique potential safety problem of Coronavirus vaccines. ...This was first found in the early 1960s with the respiratory syncytial virus [RSV] vaccines, and it was done here in Washington with the NIH and Children's National Medical Center... [S]ome of those kids that got the vaccine actually did worse, and I believe that there were two deaths in the consequence of that study. ...[W]hat happens with certain types of respiratory virus vaccines, you get immunized, and then when you get actually exposed to the virus you get this kind of paradoxical immune enhancement phenomenon. ...[I]t's a real problem for certain respiratory virus vaccines. That killed the RSV program for decades. Now the Gates Foundation is taking it up again, but when we started developing Coronavirus vaccines (and our colleagues) we noticed in laboratory animals, that they started to show some of the same immune pathology that resembled what had happened 50 years earlier.
- But we collaborated with a unique group that figured out how to solve the problem. That if you narrow it down to the smallest subunit, the piece that... [is] called the receptor binding domain, that docs with the receptor, you get protection, and you don't get that immune enhancement phenomenon. ...We proposed this to the National Institute of Allergy and Infectious Diseases. They funded it and we wound up actually making and manufacturing, in collaboration with Walter Reed Army Institute of Research, a first generation SARS vaccine. So SARS was the one that emerged in 2003... and then this new one... we call the SARS 2 Coronavirus. We had it manufactured, but then we could never get the investment to take it beyond that. ...We had the vaccine ready to go, but we couldn't move it into the clinic, because of lack of funding, because by then nobody was interested in Coronavirus vaccines.
- When the Chinese started putting up the data on Bioarchive in January-February, we saw a very close homology between the two, and realized that we may be sitting on a very attractive Coronavirus vaccine. Now, we're working... again with NIH, and we're working with BARDA and others to get the funding, but now we'll have that lag. ...[T]hese clinical trials are not going to go that quickly because of that immune enhancement. It's going to take time. ...[U]nfortunsately, some of my colleagues in the biotech industry are making these inflated claims. ...[Y]ou've seen this... in the newspapers, "We're going to have this vaccine in weeks..." What they're really seeing is that they can move a vaccine into clinical trials, but this will not go quickly because as we start vaccinating human volunteers, especially in areas where we have community transmission, we're going to have to proceed very slowly, very cautiously. The FDA is on top of that. They have a great team in place at the Center for Biologics Evaluation and Research. They're aware of the problem, but it's not going to go quickly. We are going to have to follow this very slowly, cautiously, to make certain that we're not seeing that immune enhancement. So now we're hearing projections, a year, 18 months, who knows...
- [H]ad we had those investments early on, to carry this all the way through clinical trials years ago, we could have had a vaccine ready to go.
- So we've got to figure out what the ecosystem is going to be, to develop vaccines that are not going to make money.
- The big pharma companies are still not going in. Some of the biotechs are starting to, because they're trying to really accelerate their technology... and hopefully to flip it around for something else that will make money. We need a new system in place.
Quotes about Hotez
- My friend Dr. Peter Hotez is the world's leading authority on battling tropical diseases. Worried about Zika, Ebola, West Nile virus, typhus, malaria—he is your man. ...He has tangled with the disgraced former British doctor Andrew Wakefield, who promulgated a false causal link between vaccines and autism that led to many preventable cases of measles and other diseases... Hotez does this while bearing the price of threatening, hateful e-mails and tweets from Wakefield's supporters who... keep up the vaccine-autism myth despite a mountain of evidence to the contrary.
- Arthur Caplan, Foreword to Vaccines Did Not Cause Rachel's Autism (2018) by Peter Hotez
- Peter Hotez and his wife, Ann, have an autistic daughter, Rachel. ...[W]hen anti-vaccinators impugn vaccines as the cause of autism, they... pay close attention. A man who has spent his career fighting neglected tropical diseases, sometimes with vaccines, is going to be especially and appropriately concerned when vaccines are flagged over and over again as the cause of his own daughter's health issues.
- Arthur Caplan, Foreword to Vaccines Did Not Cause Rachel's Autism (2018) by Peter Hotez
- Now, with the latest findings of Dr. Peter Hortez, we realize that there's a new dimension to extreme poverty. ...[A]nywhere where wealthy people live... Peter finds an astonishing but mostly hidden level of poverty and suffering. He has discovered that most of the poverty-related diseases... NTDs, acutally occur in the wealthiest countries and economies. ...Peter's framework... "blue marble health," means that the NTDs will be found regardless of location as long as there are places or regions where people live in desperate circumstances. ...Peter finds that if the elected leaders of the most powerful nations would simply recognize and support their own impoverished and neglected populations, a majority of our most ancient and terrible scourges could vanish. ...Currently more than a billion people live with no money and suffer from horrific NTDs. ...This must be fixed.
- Cher (Cherilyn Sarkisian), Foreword to Blue Marble Health: An Innovative Plan to Fight Diseases of the Poor Amid Wealth (2016) by Peter Hotez.